Site-saturation mutagenesis of 500 human protein domains
Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08370-4
Large-scale experimental analysis of Human Domainome 1, a library containing more than 500,000 missense mutation variants across more than 500 human protein domains, reveals that 60% of pathogenic missense variants reduce stability of protein domains.
Author Of article : Ben Lehner
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