Saturation genome editing-based clinical classification of BRCA2 variants
doi:10.1038/s41586-024-08349-1
CRISPR–Cas9-based saturation genome editing in a humanized mouse embryonic stem cell line was used for comprehensive functional characterization of single nucleotide variants in a region of BRCA2, and shows good agreement with existing variant classifications and high predictive power.
Author Of article : Shyam K. Sharan
Science history: Female chemist initially barred from research helps helps develop drug for remarkable-but-short-lived recovery in children with leukemia — Dec. 6, 1954
In December 1954, Gertrude Elion and colleagues described a new compound they had develope…
