Saturation genome editing-based clinical classification of BRCA2 variants
doi:10.1038/s41586-024-08349-1
CRISPR–Cas9-based saturation genome editing in a humanized mouse embryonic stem cell line was used for comprehensive functional characterization of single nucleotide variants in a region of BRCA2, and shows good agreement with existing variant classifications and high predictive power.
Author Of article : Shyam K. Sharan
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